Jim Rupert

Jim Rupert, Associate Professor
Jim Rupert, Associate Professor
Position / Job Title: 
Associate Professor
Position Type: 
Office Location: 
Biological Sciences Building - Rm 3032, 6170 University Blvd
Faculty Info
Lab Name: 
Genes, RNA, Informatics, and Protein (GRIP) Laboratory - (604) 822-9331
Curriculum Vitae / Background: 
  • University of Guelph B.Sc. (Genetics) 1984
  • University of Toronto M.Sc. (Medical Genetics) 1988
  • University of British Columbia Ph.D. (Zoology) 2000
  • Post-doctoral Fellow U.B.C, Dept Pathology and Laboratory Medicine 2000-2003
  • Post-doctoral Fellow Terry Fox Laboratory, B.C. Cancer Agency 2003-2004
Genetics and genomics of exercise. Human adaptation to altitude and the genetics of altitude-related illnesses. Genetic approaches to “doping” control. Cross-appointed to the Genetics Graduate Program. Associate Chair, UBC Behavioural Research Ethics Board
Courses Taught: 

KIN 191 - Functional Anatomy and Applied Physiology II
KIN 472 - Genetic issues in sports, exercise, and human performance
KIN 343 - An Introduction to the Biology of Human Athletic Performance


Funding Sources

Selected Published Refereed Papers/Publications: 

Publications (this millennium)

MacLeod KE, MacInnis MJ, Manokhina I, Rupert JL. 2013 Twin studies in altitude and hypoxia research. Aviat Space Environ Med. In press

Thomson CJ, Carlson SR, Rupert JL 2013. Association of a common D3 dopamine receptor gene variant is associated with impulsive sensation seeking in skiers and snowboarders J Res Pers. 47(2) 153–158.

Thomson CJ, Hanna, CW, Carlson SR, Rupert JL. 2013. The -521 C/T variant in the dopamine-4-receptor gene (DRD4) is associated with skiing and snowboarding behaviour. Scand J Med Sci Sports. 2012 Dec 17. doi: 10.1111/sms.12031. [Epub ahead of print] PMID:23252368

Thomson CJ, Morton KL, Carlson SR, Rupert JL. 2013. The Contextual Sensation Seeking Questionnaire for skiing and snowboarding (CSSQ-S): Development of a sport specific scale. Int J Sport Psychol. 42(6).

Schneider AJ, Fedoruk MN, Rupert JL. 2012. Human genetic variation: new challenges and opportunities for doping control. J Sport Sci. (11):1117-29. PMID: 22681541

MacInnis MJ, Rupert JL, Koehle MS. 2012. Evaluation of the balance error scoring system (BESS) test in the diagnosis of acute mountain sickness at 4380 m. High Alt Med Biol. 13(2):93-7. PMID: 22724611

Giles LV, Warburton DER, Esch BT, Fedoruk MN, Rupert JL, Taunton JE. 2012. The effects of exercise on hypoxic and normoxic conditions on endothelin-1 and arterial compliance. J Sports Sci. 30(3):261-7. PMID: 22175913

MacInnis MJ, Carter EA, Koehle MS, Rupert JL 2012. Exhaled nitric oxide is associated with acute mountain sickness susceptibility during exposure to normobaric hypoxia. Respiratory Physiol Neurobiol 180(1):40-4. PMID 22027218

MacInnis MJ, Wang P, Koehle MS, Rupert JL. The genetics of altitude tolerance: the evidence for inherited susceptibility to acute mountain sickness. J Occup Environ Med. 2011. 53(2):159-68. PMID 21270658

Rupert, JL. 2011. Genitals to genes: the history and biology of gender verification in the Olympics. Can Bull Med Hist. 28(2) 339-365.

MacInnis, MJ, Rupert JL 2011. ’ome on the range: altitude adaptation and Himalayan genomics. High Alt Med Biol.  Invited review. 12(2):133-9.

Beauchamp MR, Rhodes RE, Kreutzer C, Rupert JL. 2011. Experiential Versus Genetic Accounts of Inactivity: Implications for Inactive Participants’ Self-Efficacy Beliefs and Intentions to Exercise.Behav Med. 37(1):8-14.

Rupert JL. 2010. Will blood tell? Three recent papers demonstrate genetic selection in Tibetans. High Alt Med Biol. Invited commentary. 11(4): 307-308.

MacInnis MJ, Koehle MS, Rupert JL. 2010. The evidence for a genetic basis for altitude illness: the 2010 update. High Alt Med Biol. 11(4) 349-368.

Brown CJ, Rupert JL. 2010. Epigenetics and the role of epigenetic changes in hypoxia-induced gene expression. in Hypoxia and Exercise: Proceedings of the 16th International Hypoxia Symposium ed. Editors: RC Roach, PD Wagner, PH Hackett. Springer Academic Publishers, New York (in press)

Wang P, Koehle MS, Rupert JL. 2010. No association between alleles of the bradykinin receptor-B2 gene and acute mountain sickness. Exp Biol Med. 235(6) 737-740.

Wang P, Ha A, Kidd KK, Koehle MS, Rupert JL  2010. A variant of the endothelial nitric oxide synthase gene (NOS3) associated with AMS susceptibility is less common in the Quechua, a high-altitude native population. High Alt Med Biol. 11(1), 27-30.  

Schneider AJ, Rupert JL. 2009. Constructing winners: the science and ethics of genetically manipulating athletes. J Philos Sport. 36, 182-206.

Rupert JL. 2009. Transcriptional profiling: a potential anti-doping strategy. Scand J Med Sci Sports 19: 753–763

Wang P, Koehle MS, Rupert JL. 2009  Genotype at the Missense G894T Polymorphism (Glu298Asp) in the NOS3 Gene is Associated with the Susceptibility to Acute Mountain Sickness High Alt Med Biol. Fall;10(3):261-7.

Querido JS, Rupert JL, McKenzie DC, Sheel AW. 2009 Effects of intermittent hypoxia on the cerebrovascular responses to submaximal exercise in humans. Eur J Appl Physiol. Feb;105(3):403-9.

Wang P, Fedoruk MN, Rupert JL. 2008 Keeping Pace With Ace: Are Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Potential Doping Agents? Sports Med. 38(12):1065-79.

Rupert JL. 2008 Genomics and altitude research: what (and how) can we learn from the transcriptome. High Alt Med Biol 9(2):115-22.

Sporer BC, Sheel AW, Taunton, J. Rupert, JL, McKenzie DC. 2008. Inhaled Salbutamol and Doping Control: Effects of Dose on Urine Concentrations. Clinical Journal of Sports Medicine 18(3):282-5.

Fedoruk MN, Rupert JL. 2008. Myostatin Inhibition: A Potential Performance Enhancement Strategy? Scand J Med Sci Sports, 2008 Apr;18(2):123-31.

Witt JD, Guenette JA, Rupert JL, McKenzie DC, Sheel AW. 2007. Inspiratory muscle training attenuates the human respiratory muscle metaboreflex. J. Physiol. 584(Pt 3):1019-28.

Wang P, Koehle MS, Rupert JL. 2007 Common haplotypes in the beta-2 adrenergic gene are not associated with acute mountain sickness susceptibility in Nepalese. High Alt. Med. Biol. 8(3): 206-212.

Rupert JL and Koehle MS. 2006. The evidence for a genetic basis for altitude-related illness High Alt. Med. Biol, 7(2): 150-167

Koehle MS, Wang P, Guenette JA, Rupert JL. 2006. No association between variants in the ACE and angiotensin II receptor 1 gene and acute mountain sickness in Nepalese pilgrims to the Janai Purnima Festival at 4380 metres. High Alt. Med. Biol. 7(4):281 – 289.

Siddiqui A, Khattra J, Delaney A, Zhao Y, Astell C, Asano J, Babakaiff R, Barber S, Beland J, Brown-John M, Chand S, Charters A, Cullum R, Dhalla N, Featherstone R, Hoffman B, Holt R, Lee S, Luis de Algara T, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu A, Pandoh P, Rupert JL, Smailus D, Stott J, Tsai M, Wong D, Wu M, Yang G, Zhang I, Hirst M, Jones S, Helgason C, Simpson E, Hoodless P, Marra, M. 2005. A Mouse Atlas of Gene Expression: A public large-scale digital gene expression profiling resource from precisely defined developing C57BL/6J mouse tissues and cells. Proc Acad Natl Sci (USA) 102(51): 18485-18490.

Rupert JL. 2003. The search for genotypes that underlie human performance phenotypes. Comp. Biochem. Physiol. A 136: 191-203.

Rupert JL, Monsalve MV, Kidd KK, Tan C, Hochachka PW, Devine DV. 2003. Selective pressure has not acted against hypercoagulability alleles in high-altitude Amerindians. Ann. Hum. Genet. 67(5): 426-432.

Monsalve MV, Salzano FM, Rupert JL, Hutz MH, Hill K, Hurtado AM, Hochachka PW, Devine DV. 2003. Methylenetetrahydrofolate reductase (MTHFR) allele frequencies in Amerindians. Ann. Hum. Genet. 67(4): 367-371.

Hochachka PW, Rupert JL. 2003. Fine Tuning the HIF-1 'Global' O2 sensor for hypobaric hypoxia in Andean high-altitude natives. BioEssays. 25(5) 515-519.

Rupert JL, Kidd K, Norman LE, Monsalve MV, Hochachka PW, Devine DV. 2003. Genetic polymorphisms in the Renin-Angiotensin system in high-altitude and low-altitude Native American populations. Ann. Hum. Genet. 67(1):17-25.

Hochachka PW, Rupert JL, Goldenberg L, Gleave M, Kozlowski P. 2002. Going malignant: the hypoxia connection in prostate cancer. BioEssays 24 749-757.

Rupert JL, Hochachka PW. 2001. Genetic approaches to understanding human adaptation in the Andes. J. Exp. Biol. 204: 3151-3160.

Rupert JL, Hochachka PW. 2001. The evidence for hereditary factors contributing to high altitude adaptation in Andean natives: a review. High Alt. Med. Biol. 2(2): 235-256.

Rupert JL, Monsalve MV, Devine DV, Hochachka PW. 2000. Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population. Ann. Hum. Genet. 64 135–143.

Invited presentations

Rupert JL. Applications of genetic technology to doping control. Comparative Physiology Seminar, Department of Zoology, University of British Columbia, March 2013.

Rupert JL Gene profiling and profile of gene doping. International Convention on Science, Education and Medicine in Sport, Glasgow, Scotland, July 2012.

Rupert. JL Gene doping and genetically modified athletes.  Peak Performance Symposium (part of Sport and Society Dialogue Series and Celebrate Research Week) Vancouver March 2010.

Rupert. JL. When The Cure Is Perfection: Gene therapy and creation of perfect athletes.  Abandon Normal Devices (2010 Cultural Olympiad event, Vancouver) Feb, 2010. 

Rupert, JL Back or Ban boosters for the body and brain? The UBC Winter Games Education Initiative
UBC Robson Square Campus Vancouver, Jan 2010

Rupert JL Genes in doping and doping control.  Interhospital Cytogenetic Seminar Series, Child and Family Research Institute. Vancouver Nov 2009. 

Rupert JL. Constructing winners: the science and ethics of genetically manipulating athletes. Langara College's Sport and Technology: Philosophical Dimensions Conference, Vancouver, May 2009.

Rupert, JL Gene doping: Genes, doping, and construction of future athletes. Association of National Anti-doping Organizations workshop, Vancouver Nov 2008.

Rupert, JL. Genes, doping, and construction of future athletes. BC Association of Kinesiologists AGM, Vancouver Oct 2008.

Rupert, JL. Transgendered athletes in the Olympics (presentation and panellist) Faculty of Law, University of Victoria, Victoria, Jan 2008.

Rupert, JL. Hypoxia, EPO, and new strategies in doping control Department of Zoology, University of British Columbia, March 2007.

Rupert JL. Development of a prototype blood-based test for exogenous erythropoietin activity based on transcriptional profiling. Genome BC, Vancouver, 2007.

Rupert JL. Genetic variation and adaptation in a high altitude Andean population: single nucleotide polymorphisms and association analysis. IV World Congress on Mountain Medicine and High Altitude Physiology, Arica, Chile, 2000.

Rupert JL. Genetic adaptations to living in hypoxia: lessons from the Andes. Journal of Experimental Biology Conference (Physiological Limits to Human Performance), Flagstaff, Arizona, 2000.

a place of mind, The University of British Columbia

Faculty of Education

School of Kinesiology
210 - 6081 University Blvd. | Vancouver, B.C., Canada | V6T 1Z1
Tel: 604.822.9192
Fax: 604.822.6842
E-mail: ubc.kin@ubc.ca