Health and Integrative Physiology (HIP) Laboratory

The focus of the Health and Integrative Physiology (HIP) laboratory is on the interactions between the respiratory and cardiovascular systems. Work in our lab is directed at understanding the physiological basis and importance of cardio-respiratory interactions in different conditions such as exercise, disease, and hypoxia. We also perform studies in patient groups to further understand the potential therapeutic effects of exercise and physical activity.

The HIP lab is located in the Osborne Center on the campus of UBC. It is equipped with techniques and equipment necessary to study the respiratory and cardiovascular systems in humans at rest and during exercise. We use Doppler ultrasound to measure blood flow to limbs. We make continuous beat-by-beat measurements of arterial blood pressure. We have recently begun to record muscle sympathetic nerve activity. Techniques to measure ventilatory responsiveness to chemical stimuli (oxygen, carbon dioxide) are in place. Data collection/analysis hardware & software are available (PowerLab and LabView). The above methods permit simultaneous measures of blood flow, vascular resistance, autonomic activity, and the quantification of the temporal alignment between the neural, ventilatory and hemodynamic responses to physiological perturbations. In addition, standard exercise physiology equipment is housed within the lab (electronically braked cycle ergometer and open-circuit gas analysis system).

Doctoral Students:

  • Carli Peters, BSc, Mt. Allison University
  • Paolo Dominelli, BHK, MSc, University of British Columba
  • Kathryn Duff, BPE, University of British Columbia; MPH, University of Washington
  • Yannick Molgat-Seon, BSc, MSc, University of Ottawa
  • Joseph Welch, BSc, MRes, University of Derby (UK)

Masters Students:

  • Joshua Bovard, BSc, McGill University
  • Mick Leahy, BSc, Acadia University
  • Zoe Fetting-Winn, BKin, University of British Columbia
  • Paige Reinhard, BSc, St. Francis Xavier University

Undergraduate Students

  • Hanna Parmar, BSc
  • Grayson Allen, BKIN

Recent Undergraduate Alumni:

  • Jasmine Sears (respiratory therapy school)
  • Cara McCulloch (medical school)
  • Laura McCracken (graduate school)
  • Jacqueline Render (physiotherapist)
  • Nathan Hers (physiotherapist)
  • Ryan Koo (physiotherapist)
  • Jordon Lui (physiotherapist)

Post-Graduate Alumni:

  • Carli Peters, MSc
  • William Henderson, MD, PhD
  • Sabrina Wilkie, MSc
  • Glen Foster, Post-Doctoral Fellow
  • Josh McKay, MSc
  • Jordan Querido, MSc, PhD
  • Meaghan MacNutt, PhD
  • Jordan Guenette, MSc, PhD
  • Simone Tomczak, MSc
  • Jill Kennedy, MSc
  • Megan Sherman, MSc
  • Jonathan Witt, MSc
  • Sara Jane Lusina, MSc
  • Jennifer Richards, MSc

Potential Students:

Students interested in pursuing a graduate degree or a post doctoral fellowship are encouraged to contact Dr. Sheel directly (bill.sheel@ubc.ca).

See a list of publications on PubMed, a service of the National Library of Medicine – search Sheel AW.

* Indicates current or former student from the HIP lab

*Dominelli PB, *Henderson WR and Sheel AW.  A proportional assist ventilator to experimentally unload respiratory muscles during exercise.  Experimental Physiology 101(6):754-767, 2016.   Accompanying Editorial: Engineering a solution to explore the cardiorespiratory limits to exercise performance: take a load off!

Reid WD, Sheel AW, Shadgan B, Garland SJ and Road JD.  Recruitment and deoxygenation of selected respiratory and skeletal muscles during incremental loading in stable COPD patients.  Journal of Cardiopulmonary Rehabilitation and Prevention 36(4):279-287, 2016.

*Ramsook AH, *Koo R, *Molgat-Seon Y, *Dominelli PB, Syed N, Ryerson CJ, Sheel AW and Guenette JA.  Diaphragmatic recruitment increases during a bout of targeted inspiratory muscle training.  Medicine and Science in Sports and Exercise 48(6):1179-1186, 2016.

*Henderson WR, *Dominelli PB, *Molgat-Seon Y, Lipson R, Griesdale DEG, Sekhon M, Ayas N and Sheel AW.  Effect of tidal volume and positive end expiratory pressure on expiratory time constants in experimental lung injury.  Physiological Reports 4(5):1-11,e12737, 2016.

Sheel AW.  Sex differences in the physiology of exercise: an integrative perspective.  Experimental Physiology 101(2):211-212, 2016

Sheel AW, *Dominelli PB and *Molgat-Seon Y.  Revisiting dysanapsis: sex-based differences in airways and the mechanics of breathing during exercise.  Experimental Physiology 101(2):213-218, 2016.

*Hers N, Sawatsky BJ, and Sheel AW.  Age-related changes to wheeling efficiency and peak power output in novice able-bodied males.  Ergonomics 59(2):291-297, 2016.

Sima CA, Sheel AW, van Eeden SF, Reid WD, Taylor CM and Camp PG.  Pulse wave velocity measurements in moderate to severe chronic obstructive pulmonary disease: a reliability study.  International Journal of Cardiology 203:301-302, 2016.

*Dominelli PB, *Molgat-Seon Y, Foster GE, Dominelli GS, Haverkamp HC and Sheel AW.  Quantifying the shape of maximal expiratory flow-volume curves in healthy humans and asthmatic patients.  Respiratory Physiology and Neurobiology 220:46-53, 2016.

*Foster GE, Davies-Thompson J, *Dominelli PB, Heran MKS, Donnelly J, duManoir GR, Ainslie PN, Rauscher A and Sheel AW.  Changes in cerebral vascular reactivity and structure following prolonged exposure to high-altitude in humans.  Physiological Reports 3(12):1-6, e12647, 2015.

Larsen HB and Sheel AW.  The Kenyan runners.  Scandinavian Journal of Medicine and Science in Sports 25(Supplement S4):110-118, 2015

Calbet JAL, Jose Losa-Reyna J, Torres-Peralta R, Rasmussen P, Ponce-González JG, Sheel AW, Calle-Herrero J, Guadalupe-Grau A, Morales-Alamo D, Fuentes T, Rodriguez-Garcia L, Siebenmann C, Boushel R and Lundby C.  Limitations to oxygen transport and utilisation during sprint exercise in humans: evidence for a functional reserve in muscle O2 diffusing capacity. Journal of Physiology  593(20):4649-4664, 2015.

*Dominelli PB, *Molgat-Seon Y, Bingham D, Swartz PM, Road JD, *Foster GE and Sheel AW.  Dysanapsis and the resistive work of breathing during exercise in healthy men and women.  Journal of Applied Physiology 119(10):1105-1113, 2015.

*Henderson WR, *Molgat-Seon Y, *Dominelli PB, Brasher PM, Griesdale DE, *Foster GE, Yacyshyn A, Ayas NT and Sheel AW.  Gas density alters expiratory time constants before and after experimental lung injury.  Experimental Physiology 100(10):1217-1228, 2015.

*Dominelli PB, *Foster GE, Guenette JA, Haverkamp HC, Eves ND, Dominelli GS, *Henderson WR, O’Donnell DE and Sheel AW.  Quantifying the shape of the maximal expiratory flow-volume curve in mild COPD.  Respiratory Physiology and Neurobiology 219:30-35, 2015.

Beauchamp MR, Harden SM, Wolf SA, Rhodes RE, Liu Y, Dunlop WL, Schmader T, Sheel AW, Zumbo BD and Estabrooks PA.  GrOup based physical Activity for oLder adults (GOAL) randomized controlled trial:  study protocol.  BMC Public Health 15(592):1-11, 2015.

*Querido JS, *Welch JF, Ayas NT and Sheel AW.  Cerebrovascular response to CO2 following 10 days of intermittent hypoxia in humans.  Aerospace Medicine and Human Performance 86(9):782-786, 2015.

*Dominelli PB, *Render JN, *Molgat-Seon, *Foster GE, Romer LM and Sheel AW.  Oxygen cost of exercise hyperpnoea is greater in women compared to men.  Journal of Physiology 593(8):1965-1979, 2015.   Accompanying Editorial: Breathing in exercise: battle of the sexes.  Journal of Physiology 593(8):1763, 2015.

*Wilkie SS, *Dominelli PB, Sporer BC, Koehle MS and Sheel AW.  Heliox breathing equally influences respiratory mechanics and cycling performance in trained men and women.  Journal of Applied Physiology 118(3):255-264, 2015.

Layton AM, Armstrong HF, Moran SL, Guenette JA, Thomashow BM, Jellen PA, Bartels MN, Sheel AW and Basner RC.  Quantification of improvements in static and dynamic ventilatory measures following lung volume reduction surgery for severe COPD.  Journal of the COPD Foundation 2(1):61-69, 2015.

*MacNutt MJ, *Peters CM, *Chan C, *Moore J, *Shum S and Sheel AW.  Day-to-day variability in cardiorespiratory responses to hypoxic cycle exercise.  Applied Physiology, Nutrition and Metabolism 40(2):155-161, 2015.

Tremblay JC, Lovering AT, Ainslie PN, Stembridge M, Burgess KR, Bakker A, Donnelly J, Lucas SJE, Lewis NCS, *Dominelli PB, Henderson WR, Dominelli G, Sheel AW and Foster JE.  Hypoxia, not pulmonary vascular pressure induces blood flow through intrapulmonary arteriovenous anastomses.  Journal of Physiology 593(3):723-737, 2015.