The focus of the Health and Integrative Physiology (HIP) laboratory is on the interactions between the respiratory and cardiovascular systems. Work in our lab is directed at understanding the physiological basis and importance of cardio-respiratory interactions in different conditions such as exercise, disease, and hypoxia. We also perform studies in patient groups to further understand the potential therapeutic effects of exercise and physical activity.
The HIP lab is located in the Osborne Center on the campus of UBC. It is equipped with techniques and equipment necessary to study the respiratory and cardiovascular systems in humans at rest and during exercise. We use Doppler ultrasound to measure blood flow to limbs. We make continuous beat-by-beat measurements of arterial blood pressure. We have recently begun to record muscle sympathetic nerve activity. Techniques to measure ventilatory responsiveness to chemical stimuli (oxygen, carbon dioxide) are in place. Data collection/analysis hardware & software are available (PowerLab and LabView). The above methods permit simultaneous measures of blood flow, vascular resistance, autonomic activity, and the quantification of the temporal alignment between the neural, ventilatory and hemodynamic responses to physiological perturbations. In addition, standard exercise physiology equipment is housed within the lab (electronically braked cycle ergometer and open-circuit gas analysis system).
Research in the HIP lab is supported by the following granting agencies:
- Bruno Archiza, visiting doctoral student, Brazil
- Carli Peters, BSc, Mt. Allison University, MSc University of British Columbia
- Kathryn Duff, BPE, University of British Columbia; MPH, University of Washington
- Yannick Molgat-Seon, BSc, MSc, University of Ottawa
- Joseph Welch, BSc, MRes, University of Derby (UK)
- Joshua Bovard, BSc, McGill University
- Mick Leahy, BSc, Acadia University
- Zoe Fetting-Winn, BKin, University of British Columbia
- Paige Reinhard, BSc, St. Francis Xavier University
- Caitlin Geary, BKIN
- McKenzie Summers, BKIN
- Eric Smith, BKIN
- Hanna Parmar, BSc
- Grayson Allen, BKIN
- Jasmine Sears (respiratory therapy school)
- Cara McCulloch (medical school)
- Laura McCracken (graduate school)
- Jacqueline Render (physiotherapist)
- Nathan Hers (physiotherapist)
- Ryan Koo (physiotherapist)
- Jordon Lui (physiotherapist)
- Paolo Dominelli, BKIN, MSc, PhD
- Carli Peters, MSc
- William Henderson, MD, PhD
- Sabrina Wilkie, MSc
- Glen Foster, Post-Doctoral Fellow
- Josh McKay, MSc
- Jordan Querido, MSc, PhD
- Meaghan MacNutt, PhD
- Jordan Guenette, MSc, PhD
- Simone Tomczak, MSc
- Jill Kennedy, MSc
- Megan Sherman, MSc
- Jonathan Witt, MSc
- Sara Jane Lusina, MSc
- Jennifer Richards, MSc
Note: See a list of publications on PubMed, a service of the National Library of Medicine – search Sheel AW.
* Indicates current or former student from the HIP lab
*Dominelli PB, *Molgat-Seon Y, Griesdale DEG, *Peters CM, Blouin JS, Sekhon M, Dominelli G, *Henderson WR, Foster GE, Romer LM, Koehle MS and Sheel AW. Exercise-induced quadriceps muscle fatigue in men and women: effects of arterial oxygen content and respiratory muscle work. Journal of Physiology. (In Press)
Schaeffer MR, Ryerson CJ, Ramsook AH, *Molgat-Seon Y, Wilkie SS, Dhillon SS, Mitchell RA, Sheel AW, Khalil N, Camp PG and Guenette JA. Effects of hyperoxia on dyspnoea and exercise endurance in fibrotic interstitial lung disease. European Respiratory Journal. (In Press)
*Molgat-Seon Y, Hannan LM, *Dominelli PB, *Peters CM, Fougere RJ, McKim DA, Sheel AW and Road JD. Lung volume recruitment acutely increases respiratory system compliance in individuals with severe respiratory muscle weakness. European Respiratory Journal Open Research (In Press)
Curtelin D, Morales-Almo D, Torres-Peralta R, Rasmussen P, Martin-Rincon M, Perez-Valera M, Siebenmann C, Pérez-Suárez I, Cherouveim E, Sheel AW, Lundby and Calbet JA. Cerebral blood flow, frontal lobe oxygenation and intra-arterial blood pressure during sprint exercise in normoxia and severe acute hypoxia in humans. Journal of Cerebral Blood Flow and Metabolism (In Press)
*Henderson WR, *Molgat-Seon Y, Wim V, Lipson R, Ferreira F, Kirby M, Van Holsbeke C, *Dominelli PB, Griesdale DEG, Sekhon M, Coxson HO, Mayo J and Sheel AW. Functional respiratory imaging, regional strain, and expiratory time constants at three levels of positive end expiratory pressure in an ex vivo pig model. Physiological Reports 4(5):1-19, e13059, 2016.
*McKay JA, *McCulloch CL, *Querido JS, Foster GE, Koehle MS and Sheel AW. The effect of consistent practice of yogic breathing exercises on the human cardiorespiratory system. Respiratory Physiology and Neurobiology 233:41-51, 2016.
*Dominelli PB, *Henderson WR and Sheel AW. A proportional assist ventilator to experimentally unload respiratory muscles during exercise. Experimental Physiology 101(6):754-767, 2016. *Accompanying Editorial: Engineering a solution to explore the cardiorespiratory limits to exercise performance: take a load off!
Reid WD, Sheel AW, Shadgan B, Garland SJ and Road JD. Recruitment and deoxygenation of selected respiratory and skeletal muscles during incremental loading in stable COPD patients. Journal of Cardiopulmonary Rehabilitation and Prevention 36(4):279-287, 2016.
Ramsook AH, Koo R, *Molgat-Seon Y, *Dominelli PB, Syed N, Ryerson CJ, Sheel AW and Guenette JA. Diaphragmatic recruitment increases during a bout of targeted inspiratory muscle training. Medicine and Science in Sports and Exercise 48(6):1179-1186, 2016.
*Henderson WR, *Dominelli PB, *Molgat-Seon Y, Lipson R, Griesdale DEG, Sekhon M, Ayas N and Sheel AW. Effect of tidal volume and positive end expiratory pressure on expiratory time constants in experimental lung injury. Physiological Reports 4(5):1-11,e12737, 2016.
Sheel AW. Sex differences in the physiology of exercise: an integrative perspective. (Symposium introduction) Experimental Physiology 101(2):211-212, 2016
Sheel AW, *Dominelli PB and *Molgat-Seon Y. Revisiting dysanapsis: sex-based differences in airways and the mechanics of breathing during exercise. Experimental Physiology 101(2):213-218, 2016.
*Hers N, Sawatsky BJ, and Sheel AW. Age-related changes to wheeling efficiency and peak power output in novice able-bodied males. Ergonomics 59(2):291-297, 2016.
Sima CA, Sheel AW, van Eeden SF, Reid WD, Taylor CM and Camp PG. Pulse wave velocity measurements in moderate to severe chronic obstructive pulmonary disease: a reliability study. International Journal of Cardiology 203:301-302, 2016.
*Dominelli PB, *Molgat-Seon Y, Foster GE, Dominelli GS, Haverkamp HC and Sheel AW. Quantifying the shape of maximal expiratory flow-volume curves in healthy humans and asthmatic patients. Respiratory Physiology and Neurobiology 220:46-53, 2016.
Students interested in pursuing a graduate degree or a post doctoral fellowship are encouraged to contact Dr. Sheel directly (firstname.lastname@example.org).
Osborne Centre, Room 202
6108 Thunderbird Blvd