Health and Integrative Physiology (HIP) Laboratory

The focus of the Health and Integrative Physiology (HIP) laboratory is on the interactions between the respiratory and cardiovascular systems. Work in our lab is directed at understanding the physiological basis and importance of cardio-respiratory interactions in different conditions such as exercise, disease, and hypoxia. We also perform studies in patient groups to further understand the potential therapeutic effects of exercise and physical activity.

The HIP lab is located in the Osborne Center on the campus of UBC. It is equipped with techniques and equipment necessary to study the respiratory and cardiovascular systems in humans at rest and during exercise. We use Doppler ultrasound to measure blood flow to limbs. We make continuous beat-by-beat measurements of arterial blood pressure. We have recently begun to record muscle sympathetic nerve activity. Techniques to measure ventilatory responsiveness to chemical stimuli (oxygen, carbon dioxide) are in place. Data collection/analysis hardware & software are available (PowerLab and LabView). The above methods permit simultaneous measures of blood flow, vascular resistance, autonomic activity, and the quantification of the temporal alignment between the neural, ventilatory and hemodynamic responses to physiological perturbations. In addition, standard exercise physiology equipment is housed within the lab (electronically braked cycle ergometer and open-circuit gas analysis system).

Research in the HIP lab is supported by the following granting agencies:

People

View Dr. Sheel's profile page.

  • Carli Peters, BSc, Mt. Allison University, MSc University of British Columbia
  • Kathryn Duff, BPE, University of British Columbia; MPH, University of Washington
  • Joseph Welch, BSc, MRes, University of Derby (UK)
  • Emily Gerson, BSc, University of British Columbia
  • Mick Leahy, BSc, Acadia University
  • Zoe Fetting-Winn, BKin, University of British Columbia
  • Paige Reinhard, BSc, St. Francis Xavier University
  • Malcolm MacDonald, BKIN
  • Caitlin Geary, BKIN
  • Hanna Parmar, BSc
  • McKenzie Summers, BKIN
  • Eric Smith, BKIN
  • Grayson Allen, BKIN
  • Jasmine Sears
  • Cara McCulloch
  • Laura McCracken
  • Jacqueline Render
  • Nathan Hers
  • Ryan Koo
  • Jordon Lui
  • Bruno Archiza, visiting doctoral student, Brazil, PhD
  • Yannick Molgat-Seon, PhD
  • Joshua Bovard, MSc
  • Paolo Dominelli, BKIN, MSc, PhD
  • Carli Peters, MSc
  • William Henderson, MD, PhD
  • Sabrina Wilkie, MSc
  • Glen Foster, Post-Doctoral Fellow
  • Josh McKay, MSc
  • Jordan Querido, MSc, PhD
  • Meaghan MacNutt, PhD
  • Jordan Guenette, MSc, PhD
  • Simone Tomczak, MSc
  • Jill Kennedy, MSc
  • Megan Sherman, MSc
  • Jonathan Witt, MSc
  • Sara Jane Lusina, MSc
  • Jennifer Richards, MSc

Note: See a list of publications on PubMed, a service of the National Library of Medicine – search Sheel AW.

Selected Recent Publications

* Indicates current or former student from the HIP lab

Molgat-Seon Y*, Peters CM* and Sheel AW. Sex-differences in the human respiratory system and their impact on resting pulmonary function and the integrative response to exercise. Current Opinion in Physiology (In Press).

Parmar HR*, Sears J*, Molgat-Seon Y*, Brown C, McCulloch CL*, McCracken L*, Sheel AW and Dominelli PB*. Oral contraceptives modulate the muscle metaboreflex in healthy young women. Applied Physiology Nutrition and Metabolism (In Press).

Archiza B*, Welch JF*, Geary CM*, Allen GP*, Borghi-Silva A and Sheel AW. Temporal characteristics of exercise-induced diaphragmatic fatigue. Journal of Applied Physiology (In Press).

Molgat-Seon Y*, Dominelli PB*, Ramsook AH, Schaeffer MR, Molgat Sereacki S, Foster GE, Romer LM, Road JD, Guenette JA and Sheel AW. Independent and combined effects of age and sex on mechanical ventilatory constraint and dyspnea during exercise in healthy humans. Journal of Applied Physiology (In Press).

Schaeffer MR, Ryerson CJ, Ramsook AH, Molgat-Seon Y*, Wilkie SS, Dhillon SS, Mitchell RA, Sheel AW, Khalil N, Camp PG and Guenette JA. Neurophysiological mechanisms of exertional dyspnoea in fibrotic interstitial lung disease. European Respiratory Journal 51(1): 1701726; 1-9, 2018.

Curtelin D, Morales-Almo D, Torres-Peralta R, Rasmussen P, Martin-Rincon M, Perez-Valera M, Siebenmann C, Pérez-Suárez I, Cherouveim E, Sheel AW, Lundby and Calbet JA. Cerebral blood flow, frontal lobe oxygenation and intra-arterial blood pressure during sprint exercise in normoxia and severe acute hypoxia in humans. Journal of Cerebral Blood Flow & Metabolism 38(1):136-150, 2018.

Dominelli PB*, Archiza B*, Ramsook AH, Mitchell RA, Molgat-Seon Y*, Henderson WR, Koehle MS, Boushel R and Sheel AW. Effects of respiratory muscle work on respiratory and locomotor muscle blood flow. Experimental Physiology 102(11): 1535-1547, 2017.

Peters CM*, Welch JF*, Dominelli PB*, Molgat-Seon Y*, Romer LM, McKenzie DC and Sheel AW. Influence of inspiratory resistive loading on expiratory muscle fatigue in healthy humans.  Experimental Physiology 102(9): 1221-1233, 2017.

Archiza B*, Welch JF* and Sheel AW. Classical experiments in whole-body metabolism: closed-circuit respirometry.  European Journal of Applied Physiology 117(10):1929-1937, 2017.

Dominelli PB*, Molgat-Seon Y*, Griesdale DEG, Peters CM*, Blouin JS, Sekhon M, Dominelli G, Henderson WR, Foster GE, Romer LM, Koehle MS and Sheel AW.  Exercise-induced quadriceps muscle fatigue in men and women: effects of arterial oxygen content and respiratory muscle work. Journal of Physiology 595(15): 5227–5244, 2017.

Schaeffer MR, Ryerson CJ, Ramsook AH, Molgat-Seon Y*, Wilkie SS, Dhillon SS, Mitchell RA, Sheel AW, Khalil N, Camp PG and Guenette JA. Effects of hyperoxia on dyspnoea and exercise endurance in fibrotic interstitial lung disease. European Respiratory Journal 49(5):1602494; 1-4, 2017.

Welch JF*, Mildren RL, Zaback M, Archiza B*, Allen GP* and Sheel AW. Reliability of the diaphragmatic compound muscle action potential evoked by cervical magnetic stimulation and recorded via chest wall surface EMG. Respiratory Physiology and Neurobiology 243:101-106, 2017.

Molgat-Seon Y*, Hannan LM, Dominelli PB*, Peters CM*, Fougere RJ, McKim DA, Sheel AW and Road JD. Lung volume recruitment acutely increases respiratory system compliance in individuals with severe respiratory muscle weakness. European Respiratory Journal Open Research 3(1):1-10, 2017.

Potential Students:

Students interested in pursuing a graduate degree or a post doctoral fellowship are encouraged to contact Dr. Sheel directly (bill.sheel@ubc.ca).

Location:
Osborne Centre, Room 202
6108 Thunderbird Blvd
Vancouver, BC
V6T 1Z3

604-832-4384