SEMINAR CANCELLED: School of Kinesiology Distinguished Speaker Series: Dr. Kristin Stanford


Speaker: Dr. Kristin Stanford,  Associate Professor, Department of Physiology and Cell Biology, Department of Internal Medicine, Endocrinology Associate Director, Diabetes Metabolism Research Center, Investigator, Davis Heart and Lung Research Institute,
The Ohio State University WexnerMedical Center

HostsDr. Robert Boushel, Director, Professor, UBC School of Kinesiology and Dr. Jean Sebastien Blouin, Professor, UBC School of Kinesiology. 

Title:  “A novel role for brown adipose tissue to regulate cardiac function”

Brown adipose tissue (BAT) is an important tissue for thermogenesis, making it a potential target to decrease the risks of obesity, type 2 diabetes, and cardiovascular disease (CVD), and recent studies have also identified BAT as an endocrine organ. While a role for BAT to mediate cardiac function has been indicated, to this point there are no studies that identify a direct role for BAT to mediate cardiac function. Here, we determined that transplantation of BAT (+BAT) increasesin vivocardiac hemodynamics. Lipidomicsanalysis revealed that the lipokinemost up-regulated in +BAT mice was 12,13-diHOME. Sustained overexpression of 12,13-diHOME using tissue nanotransfectionnegated the deleterious effects of a high-fat diet on cardiac function and remodeling. We then determined that 12,13-diHOME acutely increases cardiac hemodynamics via direct effects on the cardiomyocyte. Furthermore, incubation of cardiomyocyteswith 12,13-diHOME increased mitochondrial respiration via the ryanodine receptor. The effects of 12,13-diHOME were absent inNOS1-/-mice and cardiomyocytes. We also provide the first evidence that 12,13-diHOME is decreased in human patients with heart disease, and this decrease is correlated with reduced ejection fraction. Our results identify an endocrine role for BAT to enhance cardiac function that is mediated by regulation of calcium cycling via 12,13-diHOME and NOS1