The effect of sex on the cardiovascular response to the metaboreflex during dynamic leg exercise

Principle Investigator:
Dr. Bill Sheel

The purpose of the study is to elicit a metabolically driven reflex during dynamic exercise and observe the effect of sex in the cardiovascular response.
The study requires two visits. Visit 1 entails measurements of function function, followed by a VO2max test on a bike. Visit 2 involves to bouts of exercise completed at threshold intensity (~70% max). One bout will be followed with normal recovery, and the other with 3-minutes of post-exercise occlusion. Post-exercise occlusion is a practice in which blood flow to and from the exercising limb, to isolate a metabolically driven reflex.

You may be able to participate in this study if:
– You are a man or woman between the ages of 18-40 years of age
– Can fluently read and write in English
– You do not smoke or vape
– You have normal lung function based on age- and sex-predicted values
– Have a body mass index less than 18 or greater than 30 kg/m2
– You have no symptoms of cardiopulmonary disease.
-Able to perform repeated respiratory measures

You cannot participate in the study if:
– You have a history of asthma, smoking and/or cardiopulmonary (heart and/or lung) disease
– Have any contraindications to exercise testing based on the PAR-Q+ form
– Currently smokes/vapes or previously smoked more than a 10 pack-year
– You are pregnant
– Females: Mono- or triphasic oral contraceptives or hormonal implants (Uterine or otherwise).


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