Health and Integrative Physiology (HIP) Laboratory

The focus of the Health and Integrative Physiology (HIP) laboratory is to understand how the respiratory and cardiovascular systems interact, respond and adapt to physiological stressors such as exercise, disease, and hypoxia. The interactions between the heart, vasculature, lungs, and muscles of respiration are complex with many unanswered questions remaining. Moreover, the importance of biological sex is rarely considered when exploring the complexities of cardio-respiratory interactions. A number of ongoing research studies have been designed to blend these themes. An important aim of ongoing work is to provide significant training opportunities for highly-qualified trainees ranging from undergraduates to post doctoral fellows.

The HIP lab is located in the Chan Gunn Pavilion on the campus of UBC. It is equipped with techniques and equipment necessary to study the respiratory and cardiovascular systems in humans at rest and during exercise. We use Doppler ultrasound to measure blood flow to limbs. We make continuous beat-by-beat measurements of arterial blood pressure. We have recently begun to record muscle sympathetic nerve activity. Techniques to measure ventilatory responsiveness to chemical stimuli (oxygen, carbon dioxide) are in place. Data collection/analysis hardware & software are available (PowerLab and LabView). The above methods permit simultaneous measures of blood flow, vascular resistance, autonomic activity, and the quantification of the temporal alignment between the neural, ventilatory and hemodynamic responses to physiological perturbations. In addition, standard exercise physiology equipment is housed within the lab.

Research in the HIP lab is supported by the following granting agencies:


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  • Shalaya Kipp, BA and MSc, University of Colorado Boulder
  • Mick Leahy, BSc, Acadia University; MSc, University of British Columbia
  • Joshua Taylor, BSc, University of Leeds; MSc Norwegian University of Science and Technology
  • Stephen Busch, BKIN, University of British Columbia – Okanagan; MSc, University of Alberta
  • Viviana Shiffman, BSc, Western University; MSc University of British Columbia
  • Jenna Benbaruj, BKIN University of British Columbia
  • Nikol Grishin, BKIN University of British Columbia
  • Owen Payne, BSc, Queen’s University
  • Rachel Jackman, BA, St. Olaf College
  • Sierra Arn, BKIN
  • Hira Niazi, BKIN
  • Jake Hannah, BKIN
  • Max Geise, BKIN
  • Tian Rabbani, BKIN
  • Hannah Folkmann, BKIN
  • Malcolm MacDonald, BKIN
  • Caitlin Geary, BKIN
  • Hanna Parmar, BSc
  • McKenzie Summers, BKIN
  • Eric Smith, BKIN
  • Grayson Allen, BKIN
  • Jasmine Sears, BKIN
  • Cara McCulloch, BKIN
  • Laura McCracken, BKIN
  • Jacqueline Render, BKIN
  • Nathan Hers, BKIN
  • Ryan Koo, BKIN
  • Jordon Lui, BKIN
  • Thora Rae, BKIN
  • Emily Gerson, MSc
  • Paige Reinhard, MSc
  • Carli Peters, MSc, PhD
  • Bruno Archiza, Post-Doctoral Fellow
  • Kathryn Duff, PhD
  • Zoe Fetting-Winn, MKIN
  • Joseph Welch, PhD
  • Yannick Molgat-Seon, PhD
  • Joshua Bovard, MSc
  • Paolo Dominelli, BKIN, MSc, PhD
  • William Henderson, MD, PhD
  • Sabrina Wilkie, MSc
  • Glen Foster, Post-Doctoral Fellow
  • Josh McKay, MSc
  • Jordan Querido, MSc, PhD
  • Meaghan MacNutt, PhD
  • Jordan Guenette, MSc, PhD
  • Simone Tomczak, MSc
  • Jill Kennedy, MSc
  • Megan Sherman, MSc
  • Jonathan Witt, MSc
  • Sara Jane Lusina, MSc
  • Jennifer Richards, MSc

Note: See a list of publications on PubMed, a service of the National Library of Medicine – search Sheel AW.

Selected Recent Publications

* Indicates current or former student from the HIP lab

Molgat-Seon Y*, Dominelli PB*, Peters CM*, Kipp S*, Welch JF*, Parmar HR*, Rabanni T*, Mann LM, Sawatzky MAT, Guenette JA and Sheel AW. Predictors of expiratory flow limitation during exercise in healthy men and women. Medicine and Science in Sports and Exercise (In press).

Ramsook AH, Schaeffer MR, Mitchell RA, Dhillon SS, Milne KM, Hutchinson O, Puyat JH, Koehle MS, Sheel AW and Guenette JA. Sex differences in diaphragm voluntary activation after exercise. Medicine and Science in Sports and Exercise (In press).

Peters CM*, Peters RC, Lee RD, Lam S, Sin DD, McKenzie DC and Sheel AW. Software development to optimize the minimal detectable difference in human airway images captured using optical coherence tomography. Clinical Physiology and Functional Imaging (In press).

Angus SA, Henderson WR*, Banoei MM, Molgat-Seon Y*, Peters CM*, Parmar HR*, Griesdale DEG, Shekhon M, Sheel AW, Winston BW and Dominelli PB. Therapeutic hypothermia attenuates physiologic, histologic and metabolomic markers of injury in a porcine model of acute respiratory distress syndrome. Physiological Reports 10(9):e15286, p.1-17, 2022.

Peters CM*, Leahy MG, Hohert G, Lane P, Lam S, Sin DD, McKenzie DC and Sheel AW. Airway luminal area and the resistive work of breathing during exercise in healthy young females and males. Journal of Applied Physiology 131(6): 1750-1761, 2021.

Mitchell RA, Apperly ST, Dhillon SS, Zhang J, Boyle KG, Ramsook AH, Schaeffer MR, Milne KM, Molgat-Seon Y, Sheel AW and Guenette JA. Cardiopulmonary exercise testing and inspiratory muscle training in a 59-year-old four years after an extra-pleural pneumonectomy. Journal of Applied Physiology 131(6):1701-1707, 2021.

Katayama K, Dominelli PB, Foster GE, Kipp S*, Leahy MG*, Ishida K and Sheel AW. Respiratory modulation of sympathetic vasomotor outflow during graded leg cycling. Journal of Applied Physiology 131(2):858-867, 2021.

Gee CM, Eves ND, Sheel AW and West CR. How does cervical spinal cord injury impact the cardiopulmonary response to exercise? Respiratory Physiology and Neurobiology 293:1-8, 2021.

Kipp S,* Leahy MG*, Hanna J* and Sheel AW. Partitioning the work of breathing during running and cycling using optoelectronic plethysmography. Journal of Applied Physiology 130(5):1460-1469, 2021.

Archiza B*, Leahy MG*, Kipp S* and Sheel AW. An integrative approach to the pulmonary physiology of exercise: when does sex matter? European Journal of Applied Physiology (In Press)

Beauchamp MR, Liu Y, Dunlop WL, Ruissen GR, Schmader T, Harden SM, Wolf SA, Puterman E, Sheel AW and Rhodes RE. Psychological mediators of exercise adherence among older adults in a group-based randomized trial. Health Psychology. 40(3):166-177, 2021.

Hopkins SR, Dominelli PB, Davis CK, Guenette JA, Luks AM, Molgat-Seon Y, Sá RC, Sheel AW, Swenson MD and Stickland MK. Facemasks and the cardiorespiratory response to physical activity in health and disease. Annals of the American Thoracic Society 18(3):399-407, 2021.

Peters CM*, Molgat-Seon Y*, Dominelli PB*, Lee AMD, Lane P, Lam S, and Sheel AW. Optical coherence tomography (OCT) to assess human airways: The relationship between anatomy and physiological function during dynamic exercise. Physiological Reports 9(1):e14657, 1-8, 2021.

Archiza B*, Reinhard PA*, Welch JF* and Sheel AW. Sex differences in diaphragmatic fatigue: effects of hypoxia during inspiratory loading. Journal of Physiology 599(4):1319-1333, 2021.

Ramsook AH, Molgat-Seon Y*, Boyle KG, Mitchell RA, Koehle MS, Sheel AW and Guenette JA. Reliability of diaphragm voluntary activation measurements in healthy men and women. Applied Physiology, Nutrition, and Metabolism 46(3):247-256, 2021.

Ramsook AH, Peters CM*, Leahy MG*, Archiza B*, Mitchell RA, Jasinovic T, Koehle MS, Guenette JA and Sheel AW. Near-infrared spectroscopy measures of sternocleidomastoid blood flow during exercise and hyperpnoea. Experimental Physiology 105(12):2226-2237, 2020.

Sima CA, van Eeden SF, Reid WD, Sheel AW, Benari O, Kirkham AR and Camp PG. The relationship between resting heart rate and arterial stiffness in patients with chronic obstructive pulmonary disease: implications for pulmonary rehabilitation. Canadian Journal of Respiratory, Critical Care and Sleep Medicine 4(2):83-90, 2020.

Boyle KG, Mitchell RA, Ramsook AH, Schaeffer MR, Koehle MS, Sheel AW and Guenette JA. The effect of diaphragm fatigue on the multidimensional components of dyspnoea and diaphragm electromyography during exercise in healthy males. Journal of Physiology 598(15):3223-3237, 2020.

Sheel AW and Peters CM*. (Invited Commentary) One and one is not always two: hypo- and hyper-additive effects of the chemoreflex during exercise. Journal of Physiology 598(12):2281-2282, 2020.

Sheel AW and Bailey EF. Mechanisms of respiratory modulation of cardiovascular control. Journal of Applied Physiology 128(1):212-213, 2020.

Sheel AW, Taylor JL* and Katayama K. The hyperpnoea of exercise in health: respiratory influences on neurovascular control. Experimental Physiology 105(12):1984-1989, 2020.

Leahy MG*, Peters CM*, Geary CM*, Koehle MS, McKenzie DC, Brotherhood J and Sheel AW. Diagnosis of exercise-induced bronchoconstriction in competitive swimmers: context matters. Medicine and Science in Sports and Exercise 52(9):1855-1861, 2020.

Chan M, MacInnis MJ, Koch S, MacLeod KE, Lose KR, Gallo ME, Sheel AW and Koehle MS. Cardiopulmonary demand of 16-kg kettlebell snatches in simulated Girevoy Sport. Journal of Strength and Conditioning Research 34(6):1625-1633, 2020.

Reinhard PA*, Gerson EAM*, Sheel AW and Archiza B*. Quantifying the mechanical work of breathing in men and women during rowing. European Journal of Applied Physiology 120(2):381-390, 2020.

Potential Students:

Students interested in pursuing a graduate degree or a post doctoral fellowship are encouraged to contact Dr. Sheel directly (

William Sheel, PhD
School of Kinesiology
The University of British Columbia
Vancouver Campus, 2553 Wesbrook Mall | Vancouver BC | V6T 1Z3 Canada

604 822 4459