Health and Integrative Physiology (HIP) Laboratory

The focus of the Health and Integrative Physiology (HIP) laboratory is to understand how the respiratory and cardiovascular systems interact, respond and adapt to physiological stressors such as exercise, disease, and hypoxia. The interactions between the heart, vasculature, lungs, and muscles of respiration are complex with many unanswered questions remaining. Moreover, the importance of biological sex is rarely considered when exploring the complexities of cardio-respiratory interactions. A number of ongoing research studies have been designed to blend these themes. An important aim of ongoing work is to provide significant training opportunities for highly-qualified trainees ranging from undergraduates to post doctoral fellows.

The HIP lab is located in the Chan Gunn Pavilion on the campus of UBC. It is equipped with techniques and equipment necessary to study the respiratory and cardiovascular systems in humans at rest and during exercise. We use Doppler ultrasound to measure blood flow to limbs. We make continuous beat-by-beat measurements of arterial blood pressure. We have recently begun to record muscle sympathetic nerve activity. Techniques to measure ventilatory responsiveness to chemical stimuli (oxygen, carbon dioxide) are in place. Data collection/analysis hardware & software are available (PowerLab and LabView). The above methods permit simultaneous measures of blood flow, vascular resistance, autonomic activity, and the quantification of the temporal alignment between the neural, ventilatory and hemodynamic responses to physiological perturbations. In addition, standard exercise physiology equipment is housed within the lab.

Research in the HIP lab is supported by the following granting agencies:

People

View Dr. Sheel's profile page.

  • Bruno Archiza, PhD, Federal University of São Carlos, Brazil
  • Shalaya Kipp, BA and MSc, University of Colorado Boulder
  • Carli Peters, BSc, Mt. Allison University; MSc, University of British Columbia
  • Mick Leahy, BSc, Acadia University; MSc, University of British Columbia
  • Joshua Taylor, BSc, University of Leeds; MSc Norwegian University of Science and Technology
  • Emily Gerson, BSc, University of British Columbia
  • Paige Reinhard, BSc, St. Francis Xavier University
  • Kayla Johnston, BKIN, University of British Columbia
  • Viviana Shiffman, BSc, Western University
  • Jake Hannah, BKIN
  • Max Geise, BKIN
  •  Tian Rabbani, BKIN
  • Hannah Folkmann, BKIN
  • Malcolm MacDonald, BKIN
  • Caitlin Geary, BKIN
  • Hanna Parmar, BSc
  • McKenzie Summers, BKIN
  • Eric Smith, BKIN
  • Grayson Allen, BKIN
  • Jasmine Sears, BKIN
  • Cara McCulloch, BKIN
  • Laura McCracken, BKIN
  • Jacqueline Render, BKIN
  • Nathan Hers, BKIN
  • Ryan Koo, BKIN
  • Jordon Lui, BKIN
  • Kathryn Duff, PhD
  • Zoe Fetting-Winn, MKIN
  • Joseph Welch, PhD
  • Bruno Archiza, visiting doctoral student, Brazil, PhD
  • Yannick Molgat-Seon, PhD
  • Joshua Bovard, MSc
  • Paolo Dominelli, BKIN, MSc, PhD
  • Carli Peters, MSc
  • William Henderson, MD, PhD
  • Sabrina Wilkie, MSc
  • Glen Foster, Post-Doctoral Fellow
  • Josh McKay, MSc
  • Jordan Querido, MSc, PhD
  • Meaghan MacNutt, PhD
  • Jordan Guenette, MSc, PhD
  • Simone Tomczak, MSc
  • Jill Kennedy, MSc
  • Megan Sherman, MSc
  • Jonathan Witt, MSc
  • Sara Jane Lusina, MSc
  • Jennifer Richards, MSc

Note: See a list of publications on PubMed, a service of the National Library of Medicine – search Sheel AW.

Selected Recent Publications

* Indicates current or former student from the HIP lab

Molgat-Seon Y*, Dominelli PB*, Guenette JA and Sheel AW. Modeling the effects of age and sex on the resistive and viscoelastic components of work of breathing during exercise. Experimental Physiology (In Press).

Geary CM*, Welch JF*, McDonald MR*, Peters CM*, Leahy MG*, Reinhard PA* and Sheel AW. Diaphragm fatigue and inspiratory muscle metaboreflex in men and women matched for absolute diaphragmatic work. Journal of Physiology 597(18):4797-4808, 2019.

Sheel AW and Dominelli PB*. Breathing during exercise: no such thing as a free lunch. Experimental Physiology 104(9):1333-1334, 2019.

Molgat-Seon Y*, Dominelli PB*, Peters CM*, Guenette JA, Sheel AW, Gladstone IG, Lovering AT and Duke JW. Analysis of maximal expiratory flow-volume curves in adult survivors of preterm birth. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (In Press).

Gee CM, Williams AM, Sheel AW, Eves ND and West CR. Respiratory muscle training in athletes with cervical spinal cord injury: effects of cardiopulmonary function and exercise capacity. Journal of Physiology 97(14): 3673-3685, 2019.

Welch JF*, Kipp S* and Sheel AW. Respiratory muscles during exercise: mechanics, energetics and fatigue. Current Opinion in Physiology 10:102-109, 2019.

Carter EA, Lohse KR, Sheel AW and Koehle MS. Sildenafil does not reliably improve exercise performance in hypoxia – a systematic review. BMJ Open Sport & Exercise Medicine 5(1):e000526, 1-9, 2019.

Schaeffer MR, Guenette JA, Ramsook AH, Molgat-Seon Y, Mitchell RA, Wilkie SS, Dhillon SS, Sheel AW and Ryerson CJ. Qualitative dimensions of exertional dyspnea in fibrotic interstitial lung disease. Respiratory Physiology and Neurobiology 266:1-8, 2019.

Carter EA, Sheel AW, Milsom WK and Koehle MS. Sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia. PLoS ONE 14(1): e0210841, 2019.

Molgat-Seon Y*, Ramsook AH, Peters CM*, Schaeffer MR, Dominelli PB*, Romer LM, Road JD, Guenette JA and Sheel AW. Manipulation of mechanical ventilatory constraint during moderate intensity exercise does not influence dyspnoea in healthy older men and women. Journal of Physiology 597(5):1383-1399, 2019.

Katayama K, Goto K, Shimizu K, Saito M, Ishida K, Zhang L and Sheel AW. Effect of increased inspiratory muscle work on blood flow to inactive and active limbs during submaximal dynamic exercise. Experimental Physiology 104(2):180-188, 2019.

Dominelli PB*, Molgat-Seon Y* and Sheel AW. Sex-differences in the pulmonary system influence the integrative response to exercise. Exercise and Sport Sciences Reviews 47(3):142-150, 2019.

Dominelli PB* and Sheel AW. Exercise-induced arterial hypoxemia; some answers, more questions. Applied Physiology, Nutrition, and Metabolism 46(6):571-579, 2019.

Dominelli PB*, Katayama K, Vermeulen TD, Stuckless TJR, Brown CV, Foster GE and Sheel AW. Work of breathing influences muscle sympathetic nerve activity during cycle exercise. Acta Physiologica 225(4):1-15; e13212, 2019.

Leahy MG*, Summers MN*, Peters CM*, Molgat-Seon Y*, Geary CM* and Sheel AW. The mechanics of breathing during swimming. Medicine and Science in Sports and Exercise 51(7):1467–1476, 2019.

Potential Students:

Students interested in pursuing a graduate degree or a post doctoral fellowship are encouraged to contact Dr. Sheel directly (bill.sheel@ubc.ca).

Location:
Osborne Centre, Room 202
6108 Thunderbird Blvd
Vancouver, BC
V6T 1Z3

604-832-4384