Dr. David Wright Secures CIHR Grant for Novel Antipsychotic Side Effects Study

Dr. David Wright Secures CIHR Grant for Novel Antipsychotic Side Effects Study

Dr. David Wright, in partnership with Dr. Margaret Hahn from the University of Toronto, has secured a significant grant from the Canadian Institute of Health Research (CIHR) for their project titled “Targeting the Exercise-Inducible Signalling Factor FGF21 as a Novel Approach to Alleviate the Side Effects of Antipsychotics.” This initiative addresses a pressing need within mental health treatment.

Dr. Wright’s research revolves around lifestyle interventions, such as exercise and ketogenic diets, to uncover molecular mechanisms that could be harnessed for therapeutic purposes in mitigating the adverse metabolic effects induced by antipsychotic medications in individuals with schizophrenia. Over the course of the next five years, the project will conduct a series of experiments to delve into the underlying mechanisms behind the positive effects of these interventions, with the ultimate aim of enhancing patient health outcomes.

The CIHR Project Grant Program is committed to advancing health-related knowledge and outcomes by providing support to research projects across diverse stages and disciplines. It promotes innovative approaches and encourages the translation of discoveries into practical applications, including potential commercialization.

Yeung, Clarice

Communications and Events Coordinator

Email: clarice.yeung@ubc.ca | kin.communications@ubc.ca

Phone: 604-827-1652

Office adddress: 2223 – 5955 University Boulevard, Vancouver, BC, V6T 1Z1

  • Primary contact for the School of Kinesiology’s website
  • Internal and external communications (newsletters, social media)
  • Graphic design, web design, marketing
  • Major school events coordination

Rathanaswami, Kiruthika

Program Manager, Active Kids

Email: kiruthika.rathanaswami@ubc.ca

Phone: 604 827 2454

Office address: B1104 – 5955 University Boulevard, Vancouver, BC, V6T 1Z1

  • Community program and partner management
  • Student staff management, development and training
  • Active Kids program design and delivery

Basra, Mallika

Outreach Registration Office Supervisor

Email: mallika.basra@ubc.ca

Phone: 604 822 0207

Office Address: B1502 – 5955 University Boulevard, Vancouver, BC, V6T 1Z1

Acharya, Talisa

Student Advising Assistant

Email: talisa.acharya@ubc.ca | kin.advising@ubc.ca

Office address: 2212 – 5955 University Boulevard, Vancouver, BC, V6T 1Z1

Gamu, Daniel

Assistant Professor

Email: daniel.gamu@ubc.ca

Address: War Memorial Gym, Room 35 | 6081 University Boulevard, Vancouver, BC V6T 1Z1

Other Address: BC Children’s Hospital Research Institute

Publications: Google Scholar, PubMed

Education


University of British Columbia, 2023, Michael Smith Postdoctoral Fellow (Medical Genetics)

University of Waterloo, 2017, PhD (Kinesiology)

University of Waterloo, 2011, MSc (Kinesiology)

Western University, 2007, BSc (Biology)

Courses Taught


KIN 232 Nutrition, Physical Activity, and Health

Research Interests


  • Skeletal muscle plasticity
  • Exercise physiology/metabolism
  • Biological determinants of energy expenditure
  • Obesity/diabetes pathophysiology
  • Epigenetics

Publications


See Google Scholar and PubMed for a list of current publications.

Research and Teaching


Broadly speaking, our lab examines cellular mechanisms controlling the malleable nature of both skeletal muscles and adipose tissues, two organs important for modulating energy consumption and storage. In particular, we are interested in how histones, the proteins that help package our DNA neatly inside of the nucleus, regulate gene programs important for determining muscle/adipose development and metabolism, including adaptations to exercise training and perturbations in energy balance. We use numerous cellular and molecular techniques, coupled with deep metabolic phenotyping, to tease apart how post-translational modifications to histones impact these variables in the context of health and disease. Our work spans numerous levels of investigation, from cell, tissue, to whole organism.

Potential Students


Enthusiastic and team-oriented undergraduate and graduates students are encouraged to contact me at the address above. I am deeply committed to building and fostering an equitable, diverse, and inclusive research team and lab environment, where trainees feel comfortable and supported pursuing their goals and ideas. I strongly encourage members of underrepresented groups, including (but not limited to) racialized, 2SLGBTQIA+, neurodivergent, and persons with disabilities to apply within.