Dr. Boushel’s research covers broad areas of exercise physiology including regulation of the circulation, the oxygen cascade during exercise, the adaptive response to various forms of training in healthy and clinical populations, and the effects of environment. His lab uses thermo- and dye dilution methods to measure cardiac output and limb blood flow together with arterio-venous sampling to determine systemic and regional oxygen delivery uptake during exercise. Combining muscle biopsies to measure mitochondrial respiration allows for the study of the limits of oxygen transport and utilization by Fick components of delivery and diffusion. These methods also permit the examination of muscle metabolism, substrate utilization, metabolomic, and proteomic responses to exercise and training. Dr. Boushel collaborates with colleagues Bill Sheel, Mike Koehle, and Eli Puterman at the Chan Gunn Centre for Sport and Exercise Medicine at UBC, with other scientists in the School, across UBC, and internationally.
Notarius CF, Boushel RC, MacDonald MJ, Shoemaker JK. Horizon meeting on cardiovascular physiology: Dedicated to Dr. Mike Sharratt. Appl Physiol Nutr Metab. 2018 Jul 3:1-4. doi: 10.1139/apnm-2018-0128.
Sheel AW, Boushel RC, Dempsey JA. Competition for blood flow distribution between respiratory and locomotor muscles: implications for muscle fatigue. J Appl Physiol (1985). 2018 Jun 7. doi: 10.1152/japplphysiol.00189.2018. PMID:29878876
Cardinale DA, Larsen FJ, Jensen-Urstad M, Rullman E, Søndergaard H, Morales-Alamo D, Ekblom B, Calbet JAL, Boushel R. Muscle mass and inspired oxygen influence oxygen extraction at maximal exercise: Role of mitochondrial oxygen affinity.Acta Physiol (Oxf). 2018 Jun 4:e13110. doi: 10.1111/apha.13110. [Epub ahead of print]
Heinonen I, Boushel R, Hellsten Y, Kalliokoski K. Regulation of bone blood flow in humans: The role of nitric oxide, prostaglandins, and adenosine.Scand J Med Sci Sports. 2018 May;28(5):1552-1558. doi: 10.1111/sms.13064.
Thrush AB, Antoun G, Nikpay M, Patten DA, DeVlugt C, Mauger JF, Beauchamp BL, Lau P, Reshke R, Doucet É, Imbeault P, Boushel R, Gibbings D, Hager J, Valsesia A, Slack RS, Al-Dirbashi OY, Dent R, McPherson R, Harper ME. Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism. Int J Obes (Lond). 2018 Mar;42(3):353-362. doi: 10.1038/ijo.2017.286.